Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds
نویسندگان
چکیده
منابع مشابه
2H-Chromen-4(3H)-one
In the title compound, C(9)H(8)O(2), a benzo-annulated heterocyclic ketone, the non-aromatic six-membered ring adopts an E(2) conformation. In the crystal, C-H⋯O contacts connect the mol-ecules into double sheets perpendicular to the crystallographic a axis. The centroid-centroid distance for two π-systems is 3.7699 (6) Å.
متن کامل2-(4-Chlorophenyl)chromen-4-one
The title compound, C(15)H(9)ClO(2), is a synthetic flavonoid obtained by the cyclization of 3-(4-chloro-phen-yl)-1-(2-hy-droxy-phen-yl)prop-2-en-1-one. The 4-chloro-phenyl ring is twisted at an angle of 11.54° with respect to the chromen-4-one skeleton. In the crystal, pairs of mol-ecules are inter-connected by weak Cl⋯Cl inter-actions [3.3089 (10) Å] forming dimmers which are further peripher...
متن کامل3-(4-Nitrobenzyl)-4H-chromen-4-one
In the title compound, C16H11NO4, the dihedral angle between the ten-membered chromen-4-one ring system (r.m.s. deviation = 0.0095 Å) and the benzene ring is 86.16 (5)°. In the crystal, mol-ecules are linked into a three-dimensional network by weak C-H⋯O hydrogen bonds. The crystal studied was a non-merohedral twin, with the minor twin component refining to 0.093 (1).
متن کامل3-(3-Nitrobenzyl)-4H-chromen-4-one
In the title compound, C16H11NO4, the dihedral angle between the 10-membered coplanar chromone ring system and the benzene ring is 77.83 (3)°. In the crystal, weak C-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network.
متن کاملDesign and Synthesis of Pyrrolo[2,1-a]Isoquinoline-Based Derivatives as New Cytotoxic Agents
A new series of anti-cancer agents based on 1,2-diaryl-5,6-dihydropyrrolo[2,1-a]isoquinoline scaffold containing N,N-diethylaminoethoxy, piperidinylethoxy or morpholinylethoxy group at the para position of the C-2 phenyl ring were synthesized and their cytotoxic activities were assessed against several human cancer cell lines including MCF-7 (ER positive breast cancer cell), MDA-MB231 (ER-ne...
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ژورنال
عنوان ژورنال: Research in Pharmaceutical Sciences
سال: 2019
ISSN: 1735-5362
DOI: 10.4103/1735-5362.251855